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KMID : 0382420000260040115
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Korean Journal of Environmental Health Society
2000 Volume.26 No. 4 p.115 ~ p.121
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In Vitro Magnetometry , LDH Activity and Apoptosisas Indices of Cytotoxicity in Alveolar Macrophages Exposed to Cadmium Chloride
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Cho Young-Chae
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Abstract
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To evaluate the cytotoxicity of cadmium compounds, this study was conducted to measure the in vitro magnetometry, LDH release and cellular apoptosis using alveolar macrophages of hamsters. A series of magnetometric measurements in cadmium-added groups showed a significant dose-dependent decay of the relaxation curves. The LDH release rates showed a dose-dependently increasing tendency as the dose gradually increased. The positive rates of apoptosis were significantly higher in cadmium-added groups than the control groups. Conclusively, the cytotoxicity increased in a dose dependent way as the concentration of cadmium added increased, which was reflected in the decay of relaxation curve in magnetometry, and increased LDH release rate and positive rate of apoptosis.
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